UC-Care provides new knowledge and solutions for enhanced diagnostics and antibiotic therapy of bacterial infections.
Antibiotics are essential in the cure of bacterial infections and have significantly contributed to reduce human mortality and improve animal healthcare over the last 50 years. However, antibiotic use in humans and animals has the unavoidable side effect to promote selection of resistant bacteria. The continuous spread of antibiotic resistance combined with the scarcity of new antibiotics requires a coordinated research effort.
Although we understand to some extent the molecular biology of antibiotic resistance and have identified some of the factors contributing to spread of resistant bacteria, immediate solutions are limited by the lack of new antibiotics, the long and expensive development process necessary to bring new drug leads from discovery to market, and the competing rationales prevalent in current antibiotic use.
UC-Care research is based on the One Health-concept because there is growing evidence indicating that antimicrobial resistance can be successfully combated only through intersectorial collaboration between the human and the veterinary sector.
Drug discovery alone is not sufficient to mitigate antibiotic resistance problems in the short term. A holistic and multidisciplinary approach is urgently warranted, including programmes to improve the pharmacological performance of existing antibiotics and interventions to preserve their clinical efficacy through infection control and rational antibiotic use in both human and veterinary medicine.
UC-CARE is a platform for establishment of the much needed academia-industry partnerships in this area, made possible by a 4-year grant (4,374,174 euro) from the University of Copenhagen. The center is additionally financed with contributions by Zoetis (EURO 300,000), the Department of Veterinary Disease Biology (EURO 200,000), the Department of Food and Resource Economics (EURO 73,000), and The Center for Research in Pig Production and Health (EURO 133,000).