The research programme of UC-CARE targets a number of complementary and interactive topics that are central in the fight against antibiotic resistance.
Due to the urgent need of new antibiotics and rapid diagnostic protocols allowing rational use of existing antibiotics, this important public health area can only be impacted by striking the right balance between basic and applied research.
The research programme focuses on translational research bridging the gaps between basic science, clinical research, patient care and food safety.
Methodologies span from basic microbiology techniques,sophisticated bioimaging and synthetic biology methods, over bioorganic medicinal chemistry to animal models and state-of-the-art methodology in economics, sociology, psychology and IT-innovation.
The research programme covers all seven areas and most of the concrete action points indicated in the Action Plan against Antibiotic Resistance released by the EU Commission in November 2011. The project includes 6 scientific workpackages (WP) aiming at the following objectives:
- To promote discovery of new drug targets and bring new antibiotic leads into the development process, and ultimately to patients (WP1)
- To address the urgent need for alternative methods for prevention of bacterial infections in veterinary medicine and control of antibiotic resistance in the food chain (WP2)
- To increase the clinical efficacy of existing and new antibacterial drugs by optimising treatment regimens, drug combinations and formulations (WP3)
- To facilitate optimal antibiotic use among doctors and veterinarians by providing them with evidence-based diagnostic protocols (WP4)
- To assess economic sustainability of intervention strategies in livestock and provide support for decision-making by stakeholders and risk managers (WP5)
- To determine societal and governance factors influencing antibiotic use (WP6)